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| farnesyl diphosphate synthase | ronate]] (Actonel) - 2000 * Zoledronate (Zometa, Aclasta) - 10000 Nitrogenous bisphosphonates act on bone metabolism by binding and blocking the enzyme farnesyl diphosphate synthase (FPPS) in the HMG-CoA reductase pathway (also known as the mevalonate pathway). Image:HMG-CoA reductase pathway.png|thumb|right|HMG-CoA reductase pathway Disruption of the HMG CoA-reductase pa |