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| TFPI: Tissue factor pathway inhibitor | to FXa, thrombin, or both). Quantitative or qualitative deficiency of antithrombin (inborn or acquired, e.g., in proteinuria) leads to thrombophilia. * Tissue factor pathway inhibitor (TFPI) limits the action of tissue factor (TF). It also inhibits excessive TF-mediated activation of FIX and FX. * Plasmin is generated by proteolytic cleavage of plasminogen, a plasma protein synthesi |