|
TF: tissue factor
|
e]]. It is an enzyme () of the serine protease class. ==Physiology== The main role of factor VII (FVII) is to initiate the process of coagulation in conjunction with tissue factor (TF). Tissue factor is found on the outside of blood vessels - normally not exposed to the bloodstream. Upon vessel injury, tissue factor is exposed to the blood and circulating factor VII. Once bound to |
|
TF: Tissue factor
|
appears to be the activation of factor X, one of the coagulation factors, and would account for the increased incidence of thrombosis in cancer patients. Tissue factor (TF) is also known to be present at increased levels around malignant cells. ==References== * De Cicco M. ''The prothrombotic state in cancer: pathogenic mechanisms.'' Crit Rev Oncol Hematol 2004;50 |
|
TF: tissue factor
|
Ia circulates in a higher amount than any other activated coagulation factor. * Following damage to the blood vessel, FVII leaves the circulation and comes into contact with tissue factor (TF) expressed on tissue-factor-bearing cells (stromal fibroblasts and leukocytes), forming an activated complex (TF-FVIIa). * TF-FVIIa activates FIX and FX. * FVII is itself activated by thrombin, FXI |